Facharzt für:
-Innere Medizin
-Kardiologie
-Intensivmedizin

Zusatzqualifikation für:
-Interventionelle Kardiologie
-Perkutane Mitralklappenintervention
-Hypertensiologie
-Fachgebundene genetische Beratung

• GRK: Stipendiat (Post-Doc) „Nieren- und Kreislaufforschung“ zur diabetischen Nephropathie 1993-1995 (Univ. Heidelberg)
• DFG: Einzelantrag zur diabetischen Kardiopathie (TC-64-1) 1997-1999 (Charite Berlin)
• DFG: Verlängerung des Einzelantrages zur diabetischen Kardiopathie (TC-64-2) 1999-2001 (Charite Berlin)
• GRK 865: Projektleiter zur Diabetes mellitus induzierten endothelialen Dysfunktion 2003-2007 (Charite Berlin)
• TR SFB19: Projektleiter B5 zur diastolischen Dysfunktion 2004-2012 (Charite Berlin)
• TR SFB19: Projektleiter Z3 zur Core Facility: Hämodynamische Charakterisierung 2004-2012 (Charite Berlin)
• BMBF: Plattformleiter des BCRT zur kardialen regenerativen Medizin
• BMBF: PI zu Kardiomyopathien und Herzinsuffizienz des Deutschen Zentrum für Herzkreislaufforschung (DZHK - Standort - Charite)
• EU-FP7: Projektleiter zur Diastolischen Herzinsuffizienz bei Diabetes mellitus (MEDIA-Konsortium)
  

1. Schmidt-Lucke C, Zobel T, Schrepfer S, Kühl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschöpe C. Impaired endothelial regeneration through human parvovirus B19-infected circulating angiogenic cells in cardiomyopathy. J Infect Dis. 2015 in press
2. Spillmann F, Van Linthout S, Miteva K, Lorenz M, Stangl V, Schultheiss HP, Tschöpe C. LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects. Atherosclerosis. 2014 Jan;232(1):1-9
3. Van Linthout S, Miteva K, Tschöpe C. Crosstalk between fibroblasts and inflammatory cells. Cardiovasc Res. 2014 May 1;102(2):258-69
4. Savvatis K, Pappritz K, Becher PM, Lindner D, Zietsch C, Volk HD, Westermann D, Schultheiss HP, Tschöpe C. Interleukin-23 deficiency leads to impaired wound healing and adverse prognosis after myocardial infarction. Circ Heart Fail. 2014 Jan;7(1):161-71
5. Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013 Jul 23;62(4):263-71.
6. Kasner M, Westermann D, Steendijk P, Dröse S, Poller W, Schultheiss HP, Tschöpe C. Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study. Am J Respir Crit Care Med. 2012 Jul 15;186(2):181-9.
   
7. Kasner, Westermann D, Lopez B, Gaub R, Escher F, Kühl U, Schultheiss HP, Tschöpe C. Diastolic tissue Doppler indices correlate with the degree of collagen expression and cross-linking in heart
   failure and normal ejection fraction. J Am Coll Cardiol;2011,57:977-85.
8. Westermann D, Savvatis K, Lettau O, Lindner D, Zietsch C, Escher F, Plendl J, Riad A, Schultheiss HP, Tschöpe C. Gene deletion of the matrix metalloproteinase-2 exacerbates CVB-3 induced myocarditis. Circulation, 2011, 8;124:2082-93.
   pdf - Westermann et al 2011
   
9. Miteva K, Haag M, Peng J, Savvatis K, Becher PM, Seifert M, Warstat K, Westermann D, Ringe J, Sittinger M, Schultheiss HP, Tschöpe C*, Van Linthout S*. Human cardiac-derived adherent proliferating cells reduce murine acute coxsackievirus B3-induced myocarditis. *contributed equally. PLoS One. 2011;6:e28513.  pdf - Miteva et al 2011
   
10. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier L, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. A common MLP (Muscle LIM Protein) variant is associated with cardiomyopathy. Circ Res. 2010 5;106:695-704.
11. Tschöpe C, Paulus WJ. Is echocardiographic evaluation of diastolic function useful in determining clinical care? Doppler echocardiography yields dubious estimates of left ventricular diastolic pressures. Circulation 2009 ;120:810-20
12. Westermann D, Walther T, Savvatis K, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschöpe C. Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy. Diabetes. 2009 Mar 10. [Epub ahead of print].
13. Van Linthout S, Spillmann F, Lorenz M, Meloni M, Jacobs F, Egorova M, Stangl V, De Geest B, Schultheiss HP, Tschöpe C . Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor. Hypertension. 2009;53:682-7.
14. Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U, Kroemer HK, Schultheiss HP, Tschöpe C. Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 2009,15;69:695-9.
15. Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, Meloni M, Escher E, Filenberg E; Demir O, Li J, Shakibaei M, Schimke I, Staudt A, Felix SB, Schultheiss HP, De Geest B, Tschöpe C. Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation; 2008, 117:1563-1573.
16. Westermann D, Kasner M, Steendijk P, Spillmann F, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C. An impaired Frank-Starling response during enhanced cardiac demand causing heart failure symptoms in patients with diastolic abnormalities. Circulation; 2008, 117:2051-2060.
17. Holzmann M, Nicko A, Kühl U, Noutsias M, Poller W, Hoffmann W, Morguet A, Witzenbichler B, Tschöpe C, Schultheiss HP, Pauschinger M. Complication rate in right ventricular endomyocardial biopsy - A retro- and prospective study over a 11 year period analyzing 3048 diagnostic procedures. Circulation; 2008, 52:1068-75 .
18. Riad A, Jäger S, Kallwellis-Opara A, Sobirey M, Escher F, Yaulema-Riß A, Karatas A, Heimesaat M, Bereswill S, Dragun D, Pauschinger M, Schultheiss HP, Tschöpe C: lmproved survival rate in Toll-Like Receptor-4 deficient mice after induction of myocardial infarction. J Immunology; 2008, 15180:6954-61.
19. Westermann D, Mersmann J, Melchior A, Petrik C, Freudenberger T, lettau O, Schaefer L, Lüllmann-Rauch R, Jacoby C, Schader J, Branmd-Herrmann SM, Young MF, Levkau B, Baba HH, Schultheiss HP, Unger Th, Zacharowski K, Tschöpe C, Fischer J. Biglycan is required for adaptive remodelling after myocardial infraction. Circulation; 2008, 11; 117:1269-76.
20. Kasner M, Westermann D, Steendijk P, Gaub R, Wilkenshoff U, Weitmann K, Hoffmann W, Poller W, Schultheiss HP, Pauschinger M, Tschöpe C. Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study. Circulation; 2007, 7; 116:637-47.
21. Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J.; 2007, 28:2539-50.
22. Westermann D, Rutschow S, Jager S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M, Tschöpe C. Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of Angiotensin type 1 receptor antagonism. Diabetes.; 2007, 56:641-6.
23. Tschöpe C, Bock CT, Kasner M, Noutsias M, Westermann D, Schwimmbeck PL, Pauschinger M, Poller WC, Kühl U, Kandolf R, Schultheiss H-P. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation; 2005, 111:879-86.
24. Witzenbichler B, Westermann D, Knueppel S, Schultheiss HP, Tschöpe C. Protective role of angiopoietin-1 in endotoxic Shock. Circulation; 2005, 111:97-105.
25. Tschöpe C, Walther T, Escher E, Spillmann F, Jing Du, Altmann C, Schimke I, Bader M, Sanchez-Ferrer CF, Schultheiss HP, Noutsias M. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiopathy. FASEB J; 2005, 19: 2057-9.

„Endokarditis Vorlesung 2014“

„Aortenstenose Vorlesung 2014“