- Facharzt für Innere Medizin
- Facharzt für Kardiologie
- Rettungsmedizin
- MRT-Diagnostik
- Hypertensiologe

BiomedExperts

• GRK: Stipendiat (Post-Doc) „Nieren- und Kreislaufforschung“ zur diabetischen Nephropathie 1993-1995 (Univ. Heidelberg)
• DFG: Einzelantrag zur diabetischen Kardiopathie (TC-64-1) 1997-1999 (Charite Berlin)
• DFG: Verlängerung des Einzelantrages zur diabetischen Kardiopathie (TC-64-2) 1999-2001 (Charite Berlin)
• GRK 865: Projektleiter zur Diabetes mellitus induzierten endothelialen Dysfunktion 2003-2007 (Charite Berlin)
• TR SFB19: Projektleiter B5 zur diastolischen Dysfunktion 2004-2012 (Charite Berlin)
• TR SFB19: Projektleiter Z3 zur Care Facility: Hämodynamische Charakterisierung 2004-2012 (Charite Berlin)
• BMBF: Plattformleiter des BCRT zur kardialen regenerativen Medizin
  
• EU-FP7: Projektleiter zur Diastolischen Herzinsuffizienz bei Diabetes mellitus (MEDIA-Konsortium)
  

Diastolische Herzinsuffizienz (TR/SFB 19: Projekt: B5)

Ischämische Kardiopathie (DFG: Ts 64-1, 64-2)

Diabetische Kardiopathie (DFG: Ts 64-1, 64-2)

Inflammatorische Kardiopathie (TR/SFB 19, Projekte: B5, Z3)
Sonderforschungsbereich Transregio 19

Zell-basierte Therapieansätze zur Unterstützung des kardiovaskulären Remodellings
Berlin-Brandenburg Center for Regenerative Therapies (BCRT)

1. Zelltherapie: "CAPS zur kardialen Regeneration"
2. Diagnostik: "PVB bei Knochenmarks- und Zelltransplantation"
3. Therapie : "B-Zelltherapie bei der Herzinsuffizienz"

Deutsche Gesellschaft für Kardiologie (German Society of Cardiology)
Sprecher der AG 10 "Herzinsuffizienz" der DGK
Deutsche Gesellschaft für Innere Medizin (German Society of Internal Medicine)
German Hypertension Society (Deutsche Liga zur Bekämpfung des hohen Blutdrucks)
European Society of Cardiology (ESC)
Heart Failure Association of the ESC
American Society of Cardiology
European Foundation for the study of diabetes (EFSD)
Study Group for Diastolic Heart Failure des ESC

mehr als 160 Publikationen (inkl. Übersichts- und Buchartikel, 120 internationale Originalartikel)
PUB MED

Auswahl der wichtigsten Publikationen der letzten Jahre

1. Becher PM, Lindner D, Miteva K, Savvatis K, Zietsch C, Schmack B, Van Linthout S, Westermann D, Schultheiss HP, Tschöpe C, Role of Heart Rate Reduction in the Prevention of Experimental Heart Failure: Comparison Between If-Channel Blockade and β-Receptor Blockade. Hypertension. 2012 May;59(5):949-57. Epub 2012 Apr 9. IF; 6,908. pdf - Becher et al 2012
   
2. Kasner, Westermann D, Lopez B, Gaub R, Escher F, Kühl U, Schultheiss HP, Tschöpe C. Diastolic tissue Doppler indices correlate with the degree of collagen expression and cross-linking in heart
   failure and normal ejection fraction. J Am Coll Cardiol;2011,57:977-85.IF: 12,535
3. Westermann D, Savvatis K, Lettau O, Lindner D, Zietsch C, Escher F, Plendl J, Riad A, Schultheiss HP, Tschöpe C. Gene deletion of the matrix metalloproteinase-2 exacerbates CVB-3 induced myocarditis. Circulation, 2011, 8;124:2082-93. IF: 14,930
   pdf - Westermann et al 2011
   
4. Miteva K, Haag M, Peng J, Savvatis K, Becher PM, Seifert M, Warstat K, Westermann D, Ringe J, Sittinger M, Schultheiss HP, Tschöpe C*, Van Linthout S*. Human cardiac-derived adherent proliferating cells reduce murine acute coxsackievirus B3-induced myocarditis. *contributed equally. PLoS One. 2011;6:e28513. IF: 4,351 pdf - Miteva et al 2011
   
5. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier L, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. A common MLP (Muscle LIM Protein) variant is associated with cardiomyopathy. Circ Res. 2010 5;106:695-704. IF: 9,989
6. Tschöpe C, Paulus WJ. Is echocardiographic evaluation of diastolic function useful in determining clinical care? Doppler echocardiography yields dubious estimates of left ventricular diastolic pressures. Circulation 2009 ;120:810-20; IF: 14,959
7. Westermann D, Walther T, Savvatis K, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschöpe C. Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy. Diabetes. 2009 Mar 10. [Epub ahead of print]. IF: 8,261
8. Van Linthout S, Spillmann F, Lorenz M, Meloni M, Jacobs F, Egorova M, Stangl V, De Geest B, Schultheiss HP, Tschöpe C . Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor. Hypertension. 2009;53:682-7. IF: 7,194
9. Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U, Kroemer HK, Schultheiss HP, Tschöpe C. Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 2009,15;69:695-9. IF: 7,672
10. Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, Meloni M, Escher E, Filenberg E; Demir O, Li J, Shakibaei M, Schimke I, Staudt A, Felix SB, Schultheiss HP, De Geest B, Tschöpe C. Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation; 2008, 117:1563-1573. IF: 12,755
11. Westermann D, Kasner M, Steendijk P, Spillmann F, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C. An impaired Frank-Starling response during enhanced cardiac demand causing heart failure symptoms in patients with diastolic abnormalities. Circulation; 2008, 117:2051-2060. IF: 12,755
12. Holzmann M, Nicko A, Kühl U, Noutsias M, Poller W, Hoffmann W, Morguet A, Witzenbichler B, Tschöpe C, Schultheiss HP, Pauschinger M. Complication rate in right ventricular endomyocardial biopsy - A retro- and prospective study over a 11 year period analyzing 3048 diagnostic procedures. Circulation; 2008, 52:1068-75 . IF: 12,755
13. Riad A, Jäger S, Kallwellis-Opara A, Sobirey M, Escher F, Yaulema-Riß A, Karatas A, Heimesaat M, Bereswill S, Dragun D, Pauschinger M, Schultheiss HP, Tschöpe C: lmproved survival rate in Toll-Like Receptor-4 deficient mice after induction of myocardial infarction. J Immunology; 2008, 15180:6954-61. IF: 6,068.
14. Westermann D, Mersmann J, Melchior A, Petrik C, Freudenberger T, lettau O, Schaefer L, Lüllmann-Rauch R, Jacoby C, Schader J, Branmd-Herrmann SM, Young MF, Levkau B, Baba HH, Schultheiss HP, Unger Th, Zacharowski K, Tschöpe C, Fischer J. Biglycan is required for adaptive remodelling after myocardial infraction. Circulation; 2008, 11; 117:1269-76. IF: 12,755
15. Kasner M, Westermann D, Steendijk P, Gaub R, Wilkenshoff U, Weitmann K, Hoffmann W, Poller W, Schultheiss HP, Pauschinger M, Tschöpe C. Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study. Circulation; 2007, 7; 116:637-47. IF: 12,755
16. Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J.; 2007, 28:2539-50. IF: 7,924
17. Westermann D, Rutschow S, Jager S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M, Tschöpe C. Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of Angiotensin type 1 receptor antagonism. Diabetes.; 2007, 56:641-6. IF: 8,261
18. Tschöpe C, Bock CT, Kasner M, Noutsias M, Westermann D, Schwimmbeck PL, Pauschinger M, Poller WC, Kühl U, Kandolf R, Schultheiss H-P. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation; 2005, 111:879-86. IF: 12,755
19. Witzenbichler B, Westermann D, Knueppel S, Schultheiss HP, Tschöpe C. Protective role of angiopoietin-1 in endotoxic Shock. Circulation; 2005, 111:97-105. IF: 12,755
20. Tschöpe C, Walther T, Escher E, Spillmann F, Jing Du, Altmann C, Schimke I, Bader M, Sanchez-Ferrer CF, Schultheiss HP, Noutsias M. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiopathy. FASEB J; 2005, 19: 2057-9. IF: 6,791